Breast cancer is the most common cancer affecting women of reproductive age worldwide. It can be hormone-dependent or non hormone-dependent, and early detection significantly improves survival. It’s well established that prolonged exposure to oestrogen can increase the risk of developing certain types of breast cancer.
This often raises an important question for women considering fertility treatment: could the hormones used during ovarian stimulation for IVF increase breast cancer risk?
Over the years, researchers have explored this possible connection, but the results have not always been consistent. To bring clarity, a team from St Vincent’s University Hospital in Dublin conducted a comprehensive meta-analysis* in 2022, reviewing data from multiple studies on IVF and breast cancer risk.
The findings were reassuring — there was no significant association found between fertility treatments and breast cancer. Even after six or more cycles of IVF, the data showed no increased risk.
The conclusion is clear: current evidence indicates that hormones used to stimulate the ovaries for IVF do not increase the risk of breast cancer. Women considering fertility treatment can take comfort in knowing that, based on the best available research, IVF remains a safe option in this regard.
Dr Luciano Nardo, Founder & President of NOW-fertility and Consultant in Reproductive Medicine & Infertility, comments “Whilst the published evidence brings some reassurance, it is however important that women at risk undergo investigations and receive adequate counselling prior to commencing any hormonal stimulation”.
Dr Antoine Abu Musa, Chief Medical Officer at NOW-fertility, comments “Women can choose IVF with confidence, knowing that it doesn’t increase your risk of breast cancer even after multiple cycles. However, if you have any pre-existing risk or relevant family history, we would always advise undergoing the appropriate investigations before starting your treatment”.
At NOW-fertility, our experienced Fertility Consultants are here to support you at every stage of your journey.
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*Fertility treatment and breast-cancer incidence: meta-analysis Carolyn Cullinane, Hannah Gillan, James Geraghty, Denis Evoy, Jane Rothwell, Damian McCartan, Enda W. McDermott and Ruth S. Prichard
https://doi.org/10.1093/bjsopen/zrab149
Published by NOW-fertility’s Communication Department.
Communication Manager: Annette Eckersley
E: annetteeckersley@now-fertility.com
This information was correct at the time of publishing and may not reflect our current practices, prices or regulations.
