NOW-fertility

A failed IVF transfer is particularly disappointing when the embryo has been tested by PGT-A and found to be chromosomally normal (euploid). After repeated failures, patients often wonder whether there is an underlying implantation problem and whether additional investigations or treatments are needed. A large 2026 study in Fertility and Sterility* provides reassuring—but also thought-provoking—evidence.

Most embryos that develop into blastocysts do so 5 days after fertilisation. Traditionally, this is the stage that has been considered the most likely to result in a successful pregnancy. However, some embryos take a day longer to reach the same stage, but may still be suitable for transfer. A new study* aimed to investigate

Implantation is the process by which a transferred embryo attaches to and embeds in the uterine lining (endometrium). For a day 5 embryo, this usually occurs within the first 24 hours following transfer, while for a day 3 embryo it typically happens within 2–4 days. Without successful implantation, pregnancy cannot develop. If implantation fails on

Anti-Müllerian Hormone (AMH) is one of the most commonly used tests to assess ovarian reserve. It provides an estimate of the number of eggs remaining in the ovaries and helps fertility specialists predict how the ovaries may respond to treatment. When AMH levels are low, it generally indicates that fewer follicles are available to respond